abstract：:Microvascular injury is present in a large proportion of patients with ST-elevation myocardial infarction (STEMI) despite successful revascularization. Ticagrelor potentially mitigates this process by exerting additional adenosine-mediated effects. This study aims to determine whether ticagrelor is associated with a b...

journal_title：Journal of cardiovascular translational research

authors： Janssens GN,van Leeuwen MAH,van der Hoeven NW,de Waard GA,Nijveldt R,Diletti R,Zijlstra F,von Birgelen C,Escaned J,Valgimigli M,van Royen N

更新日期：2016-06-01 00:00:00

abstract：:The increase in cardiovascular disease and metabolic syndrome incidence following the onset of menopause has highlighted the role of estrogen as a cardiometabolic protective agent. Specifically regarding the heart, estrogen induced an improvement in cardiac function, preserved calcium homeostasis, and inhibited the mi...

journal_title：Journal of cardiovascular translational research

authors： Sivasinprasasn S,Shinlapawittayatorn K,Chattipakorn SC,Chattipakorn N

更新日期：2016-02-01 00:00:00

abstract：:The goal of this paper is to provide an updated review for scientists and clinicians on the major areas in cardiovascular medicine published in the Journal. Leading topics in regenerative and personalized medicine are presented along with a critical overview of the field. New standards in large preclinical animal mode...

journal_title：Journal of cardiovascular translational research

authors： Barbato E,Barton PJ,Bartunek J,Huber S,Ibanez B,Judge DP,Lara-Pezzi E,Stolen CM,Taylor A,Hall JL

更新日期：2015-11-01 00:00:00

abstract：:Cardiac rehabilitation (CR) following myocardial infarction is vastly underused. As such, the aim of this study was to test a digital health intervention (DHI) as an adjunct to CR. Patients undergoing standard Mayo Clinic CR were recruited prior to CR (n = 25) or after 3 months CR (n = 17). Changes in risk factors and...

journal_title：Journal of cardiovascular translational research

authors： Widmer RJ,Allison TG,Lerman LO,Lerman A

更新日期：2015-07-01 00:00:00

abstract：:The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, u...

journal_title：Journal of cardiovascular translational research

authors： Costa F,Ariotti S,Valgimigli M,Kolh P,Windecker S,Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS).

更新日期：2015-06-01 00:00:00

abstract：:CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in athero...

journal_title：Journal of cardiovascular translational research

authors： Wang C,Jin R,Zhu X,Yan J,Li G

更新日期：2015-02-01 00:00:00

abstract：:Infusion catheters, when used in combination with balloons, are subjected to pressure created by inflation of the balloon. The compression can reduce the catheter flow area and cause elevated shear stresses in the fluid. A model and experiments were developed with a range of applied balloon pressures to investigate wh...

journal_title：Journal of cardiovascular translational research

authors： Dib N,Schwalbach DB,Plourde BD,Kohler RE,Dana D,Abraham JP

更新日期：2014-12-01 00:00:00

abstract：:Oxidation-specific epitopes (OSE) within developing atherosclerotic lesions are key antigens that drive innate and adaptive immune responses in atherosclerosis, leading to chronic inflammation. Oxidized phospholipids and malondialdehyde-lysine epitopes are well-characterized OSE present in human atherosclerotic lesion...

journal_title：Journal of cardiovascular translational research

authors： Briley-Saebo K,Yeang C,Witztum JL,Tsimikas S

更新日期：2014-11-01 00:00:00

abstract：:Blood-based biomarker testing of insulin resistance (IR) and beta cell dysfunction may identify diabetes risk earlier than current glycemia-based approaches. This retrospective cohort study assessed 1,687 US patients at risk for cardiovascular disease (CVD) under routine clinical care with a comprehensive panel of 19 ...

journal_title：Journal of cardiovascular translational research

authors： Varvel SA,Voros S,Thiselton DL,Pottala JV,Dall T,Warnick GR,McConnell JP,Ghaedi L,Sasinowski M,Graham T

更新日期：2014-08-01 00:00:00

abstract：:Heart failure (HF) and type 2 diabetes mellitus (T2DM) exhibit a well-established interrelationship and a growing prevalence, in particular in elderly people. Cardiac resynchronization therapy (CRT) has been shown to improve myocardial function in patients with HF and cardiac dyssynchrony. However, reports on CRT in d...

journal_title：Journal of cardiovascular translational research

authors： Sardu C,Marfella R,Santulli G

更新日期：2014-04-01 00:00:00

abstract：:Sympathoactivation is a prominent feature of heart failure (HF). Its role in cardiac remodeling and arrhythmogenesis is well-recognized today, although incomplete understanding of autonomic mechanisms was a barrier to development of contemporary medical therapies. Despite widespread availability of drugs and devices, ...

journal_title：Journal of cardiovascular translational research

authors： Gronda E,Lovett EG,Tarascio M,Georgakopoulos D,Grassi G,Vanoli E

更新日期：2014-04-01 00:00:00

abstract：:The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats and may play a role in pathogenesis of rheumatic heart disease. To identify the epitopes of M5 protein that produce valvulitis, synthetic peptides spanning A, B, and C repeat regions contained within the extracellular dom...

journal_title：Journal of cardiovascular translational research

authors： Kirvan CA,Galvin JE,Hilt S,Kosanke S,Cunningham MW

更新日期：2014-03-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in men and women in the USA; yet, coronary artery disease (CAD) continues to be underrecognized and underdiagnosed in women. Noninvasive and invasive imaging techniques are constantly being developed in order to more accurately assess CAD. At the same time, the impa...

journal_title：Journal of cardiovascular translational research

authors： Ng VG,Meller S,Shetty S,Lansky AJ

更新日期：2013-10-01 00:00:00

abstract：:We examined whether there is a relationship between repolarization abnormalities on electrocardiography (EKG) and deformation abnormalities by echocardiography. Analysis of baseline EKGs and mechanical (echo-based deformation) changes was performed in 128 patients with a clinical diagnosis of hypertrophic cardiomyopat...

journal_title：Journal of cardiovascular translational research

authors： Lin X,Liang HY,Pinheiro A,Dimaano V,Sorensen L,Aon M,Tereshchenko LG,Chen Y,Xiang M,Abraham TP,Abraham MR

更新日期：2013-08-01 00:00:00

abstract：:Comprehensive diagnostic criteria, accurate prognostic indicators, and effective treatment for patients with heart failure and a preserved ejection fraction (HFpEF) represent a critically important unmet need in cardiovascular medicine. Novel approaches to fill this unmet need are likely to be facilitated by targeting...

journal_title：Journal of cardiovascular translational research

authors： Zile MR,Baicu CF

更新日期：2013-08-01 00:00:00

abstract：:Biomarkers of blood lipid modification and oxidative stress have been associated with increased cardiovascular morbidity. We sought to determine whether these biomarkers were related to functional indices of stenosis severity among patients with stable coronary artery disease. We studied 197 consecutive patients with ...

journal_title：Journal of cardiovascular translational research

authors： Muller O,Ntalianis A,Wijns W,Delrue L,Dierickx K,Auer R,Rodondi N,Mangiacapra F,Trana C,Hamilos M,Valentin E,De Bruyne B,Barbato E,Bartunek J

更新日期：2013-08-01 00:00:00

abstract：:Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) a...

journal_title：Journal of cardiovascular translational research

authors： Birck MM,Saraste A,Hyttel P,Odermarsky M,Liuba P,Saukko P,Hansen AK,Pesonen E

更新日期：2013-08-01 00:00:00

abstract：:This manuscript reviews the studies performed with ALX-0081 (INN: caplacizumab), a Nanobody targeting von Willebrand factor, in the context of current antithrombotic therapy in coronary artery disease. ALX-0081 specifically inhibits platelet adhesion to the vessel wall, and may control platelet aggregation and subsequ...

journal_title：Journal of cardiovascular translational research

authors： Bartunek J,Barbato E,Heyndrickx G,Vanderheyden M,Wijns W,Holz JB

更新日期：2013-06-01 00:00:00

abstract：:A number of genetic variants have been identified in the lipoprotein lipase (LPL) gene. We aimed to investigate the possible associations between LPL gene and apolipoprotein C3 (APOC3) gene polymorphisms with coronary artery disease (CAD) and its severity, as well as the interaction between these polymorphisms and cla...

journal_title：Journal of cardiovascular translational research

authors： Abd-El-Aziz TA,Mohamed RH,El-Shal AS

更新日期：2013-06-01 00:00:00

abstract：:Variability of response to clopidogrel and prasugrel is a multifactorial process, with clinical consequences, and drug-drug interactions have been proposed as potential factors. Biological modulation of clopidogrel response has been demonstrated for atorvastatin and omeprazole. However, investigations assessing clinic...

journal_title：Journal of cardiovascular translational research

authors： Cuisset T,Quilici J

更新日期：2013-06-01 00:00:00

abstract：:In patients with an acute coronary syndrome (ACS), inhibition of the platelet P2Y12 receptor is standard of care. The shortcomings of the most commonly used P2Y12 receptor inhibitor clopidogrel-that is its delayed onset of action, its interindividual response variability, and the phenomenon of high on-treatment platel...

journal_title：Journal of cardiovascular translational research

authors： Orban M,Sibbing D

更新日期：2013-06-01 00:00:00

abstract：:One of the first principles taught to medical students when they begin their study of human anatomy is that all structures within the body should be described as seen in the anatomical position. In this position, the subject is standing upright and facing the observer. The observer then views left-sided structures to ...

journal_title：Journal of cardiovascular translational research

authors： Anderson RH,Spicer DE,Hlavacek AJ,Hill A,Loukas M

更新日期：2013-04-01 00:00:00

abstract：:It is just over 100 years since details emerged of the anatomical arrangement of the histologically specialised cardiomyocytes responsible for initiation and propagation of the cardiac impulse. Shortly thereafter, histological criteria were established to permit their location in autopsied human hearts. These criteria...

journal_title：Journal of cardiovascular translational research

authors： Anderson RH,Boyett MR,Dobrzynski H,Moorman AF

更新日期：2013-04-01 00:00:00

abstract：:The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master gene for skeletal muscle transdifferentiation. More recently, the induction of pluripotency in somatic cells using a combination of stem cell-specific transcription factors has been reporte...

journal_title：Journal of cardiovascular translational research

authors： Inagawa K,Ieda M

更新日期：2013-02-01 00:00:00

abstract：:Fibroblasts play a major role in normal cardiac physiology and in the response of the heart to injury and disease. Cardiac electrophysiological research has primarily focused on the mechanisms of remodeling that accompany cardiac disease with an emphasis on myocyte electrophysiology. Recently, there has been increasin...

journal_title：Journal of cardiovascular translational research

authors： Vasquez C,Morley GE

更新日期：2012-12-01 00:00:00

abstract：:Across biomedicine, there is a major drive to develop stem cell (SC) treatments for debilitating diseases. Most effective treatments restore an embryonic phenotype to adult SCs. This has led to two emerging paradigms in SC biology: the application of developmental biology studies and the manipulation of the SC niche. ...

journal_title：Journal of cardiovascular translational research

authors： Balmer GM,Riley PR

更新日期：2012-10-01 00:00:00

abstract：:Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the d...

journal_title：Journal of cardiovascular translational research

authors： Costacou T,Levy AP

更新日期：2012-08-01 00:00:00

abstract：:Both Type 1 and Type 2 diabetes can lead to debilitating microvascular complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as cardiovascular diseases including atherosclerosis and hypertension. Diabetic complications have been attributed to several contributing fa...

journal_title：Journal of cardiovascular translational research

authors： Natarajan R,Putta S,Kato M

更新日期：2012-08-01 00:00:00

abstract：:The pathophysiological abnormalities associated with increased arterial stiffness and/or abnormal pressure wave reflection may play crucial roles in increasing the risk of development of cardiovascular events. On the other hand, prehypertension, defined as a systolic blood pressure of 120-139 and/or a diastolic blood ...

journal_title：Journal of cardiovascular translational research

authors： Tomiyama H,Yamashina A

更新日期：2012-06-01 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the u...

journal_title：Journal of cardiovascular translational research

authors： Strik M,van Middendorp LB,Vernooy K

更新日期：2012-04-01 00:00:00

abstract：:The hemodynamic, mechanical and electrical effects of cardiac resynchronization therapy (CRT) occur immediate and are lasting as long as CRT is delivered. Therefore, it is reasonable to assume that acute hemodynamic effects should predict long-term outcome. However, in the literature there is more evidence against tha...

journal_title：Journal of cardiovascular translational research

authors： Prinzen FW,Auricchio A

更新日期：2012-04-01 00:00:00

abstract：:Proper atrioventricular canal (AVC) patterning and subsequent valvulogenesis is a complex process, and defects can result in disease or early death. The zebrafish Danio rerio has become a useful model system for studying AVC development, and much progress has been made in dissecting out the critical steps. Here, we re...

journal_title：Journal of cardiovascular translational research

authors： Peal DS,Lynch SN,Milan DJ

更新日期：2011-12-01 00:00:00

abstract：:Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the stud...

journal_title：Journal of cardiovascular translational research

authors： Prichard HL,Manson RJ,DiBernardo L,Niklason LE,Lawson JH,Dahl SL

更新日期：2011-10-01 00:00:00

abstract：:Cardiac magnetic resonance imaging (CMR) has become a reference standard modality for imaging of left ventricular (LV) structure and function and, using late gadolinium enhancement, for imaging myocardial infarction. Emerging CMR techniques enable a more comprehensive examination of the heart, making CMR an excellent ...

journal_title：Journal of cardiovascular translational research

authors： Vandsburger MH,Epstein FH

更新日期：2011-08-01 00:00:00

abstract：:The implantation of ventricular assist devices (VADs) is a valuable option in patients with end-stage heart failure. The number of VAD implantations is growing worldwide. Between July 1987 and July 2010, we implanted 1,598 VADs in 1,455 patients. The majority were male (81.0%), and their mean age was 49.4 years (range...

journal_title：Journal of cardiovascular translational research

authors： Krabatsch T,Schweiger M,Stepanenko A,Kukucka M,Vierecke J,Lehmkuhl HB,Huebler M,Hennig E,Potapov E,Hetzer R

更新日期：2011-06-01 00:00:00

abstract：:In this article, the available evidence about the functional effects of the contractile protein mutations that cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) is assessed. The molecular mechanism of the contractile apparatus of cardiac muscle and its regulation by Ca(2+) and PKA phosphorylatio...

journal_title：Journal of cardiovascular translational research

authors： Marston SB

更新日期：2011-06-01 00:00:00

abstract：:The costs and efforts for sample preparation of hundreds of individuals, their genomic enrichment for regions of interest, and sufficient deep sequencing bring a significant burden to next-generation sequencing-based experiments. We investigated whether pooling of samples at the level of genomic DNA would be a more ve...

journal_title：Journal of cardiovascular translational research

authors： Harakalova M,Nijman IJ,Medic J,Mokry M,Renkens I,Blankensteijn JD,Kloosterman W,Baas AF,Cuppen E

更新日期：2011-06-01 00:00:00

abstract：:The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods o...

journal_title：Journal of cardiovascular translational research

authors： Dib N,Khawaja H,Varner S,McCarthy M,Campbell A

更新日期：2011-04-01 00:00:00

abstract：:The Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations was held in Madrid on the 6th and 7th of May 2010. Gathering for the seventh consecutive year the most relevant researchers and opinion leaders on cardiovascular cell therapy, it has become the most important worldwide event on thi...

journal_title：Journal of cardiovascular translational research

authors： Gutiérrez E,Sanz-Ruiz R,Alvarez EV,Villa A,Fernández L,Vázquez S,Lorenzo J,Fernández-Santos E,Sánchez PL,Fernández-Avilés F

更新日期：2011-04-01 00:00:00

abstract：:Reperfusion injury may offset the optimal salvage of myocardium achieved during primary coronary angioplasty. Thus, coronary reperfusion must be combined with cardioprotective adjunctive therapies in order to optimize myocardial salvage and minimize infarct size. Forty-three patients with their first ST-elevation myoc...

journal_title：Journal of cardiovascular translational research

authors： Garcia S,Henry TD,Wang YL,Chavez IJ,Pedersen WR,Lesser JR,Shroff GR,Moore L,Traverse JH

更新日期：2011-02-01 00:00:00